感染症ワクチン開発研究部門とは
私たちは、消化器・呼吸器に代表される粘膜免疫機構を体内外環境生態システムとして捉え、粘膜における「共生と排除」の誘導と制御機構についての解明を進めてきました。その成果は、注射針不要な次世代型ワクチン「粘膜ワクチン」―コメ型経口ワクチン (MucoRice) 、カチオン化ナノゲル型経鼻ワクチン (cCHP) ―の開発研究につながり、ヒトへの応用に向けた研究開発を進めています。
メンバー
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| 職位 | 氏名 | 所属 | 職名 | researchmap |
|---|---|---|---|---|
| 部門長 | 清野 宏 | 未来医療教育研究機構 | 特任教授 | researchmap |
| 倉島 洋介 | 国際高等研究基幹 | 准教授 | researchmap | |
| 藤橋 浩太郎 | 医学部附属病院 | 特任教授 | researchmap | |
| 中橋 理佳 | 医学部附属病院 | 特任准教授 | researchmap | |
| 後藤 義幸 | 真菌医学研究センター | 准教授 | researchmap |
研究業績
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- Yuki, Y., Nojima, Kashima, K., Sugiura, K., Maruyama, S., Kurokawa, S., Yamanoue, T., Nakahashi-Ouchida, R., Nakajima, H., Hiraizumi, T., Kohno, H., Goto, E., Fujihashi, K. and Kiyono, H. 2022. Oral MucoRice-CTB vaccine is safe and immunogenic in healthy US adults. Vaccine (in revision)
- Kamioka, M., Goto, Y., Nakamura, K., Yokoi, Y., Sugimoto, R., Ohira, S., Kurashima, Y., Umemoto, S., Sato, S., Kunisawa, J., Takahashi, Y., Domino, S.E., Renauld, J-C., Nakae, S., Iwakura, Y., Peter B.E., Ayabe, T. and Kiyono, H. 2022. Intestinal commensal microbiota and cytokines regulate Fut2+ Paneth cells for gut defense. Proc. Natl. Acad. Sci. USA. 119: e2115230119.
- Speciale, I., Uto, T., Masui, S., Sturiale, L., Garozzo, D., Hosomi, K., Shibata, N., Kabayama, K., Fujimoto, Y., Silipo, A., Kunisawa, J., Kiyono, H., Molinaro, A., and Fukase, K. 2021. Lipopolysaccharide from gut-associated lymphoid tissue-resident Alcaligenes faecalis: Complete structure determination and chemical synthesis of its Lipid As. Angew Chem Int Ed Engl. 60: 10023-10031.
- Liu, Z., Hosomi, K., Shimoyama, A., Yoshii, K., Sun, X., Lan, H., Wang, Y., Yamaura, H., Kenneth, D., Saika, A., Nagatake, T., Kiyono, H., Fukase, K. and Kunisawa, J. 2021. Chemically synthesized alcaligenes lipid A as an adjuvant to augment immune responses to haemophilus influenzae type B conjugate vaccine. Front. Pharmacol. 12: 763657.
- Kurashima, Y., Kigoshi, T., Murasaki, S., Arai, F., Shimada, K., Seki, N., Kim, Y.G., Hase, K., Ohno, H., Kawano, K., Ashida, H., Suzuki, T., Morimoto, M., Saito, Y., Sasou, A., Goda, Y., Yuki, Y., Inagaki, Y., Iijima, H., Suda, W., Hattori, M. and Kiyono, H. 2021. Pancreatic glycoprotein 2 is a first line of defense for mucosal protection in intestinal inflammation. Nat. Commun. 12: 1067.
- Yuki, Y., Nojima, M., Hosono, O., Tanaka, H., Kimura, Y., Satoh, T., Imoto, S., Uematsu, S., Kurokawa, S., Kashima, K., Mejima, M., Nakahashi-Ouchida, R., Uchida, Y., Marui, T., Yoshikawa, N., Nagamura, F., Fujihashi, K. and Kiyono, H. 2021. Assessment of oral MucoRice-CTB vaccine for the safety and microbiota-dependent immunogenicity in humans: A randomized trial. Lancet Microbe. 2: e430.
- Nakahashi-Ouchida, R., Uchida, Y., Yuki, Y., Katakai, Y., Yamanoue, T., Ogawa, H., Munesue, Y., Nakano, N., Hanari, K., Miyazaki, T., Saito, Y., Umemoto, S., Sawada, S.I., Mukerji, R., Briles, D.E., Yasutomi, Y., Akiyoshi, K. and Kiyono, H. 2021. A nanogel-based trivalent PspA nasal vaccine protects macaques from intratracheal challenge with pneumococci. Vaccine 39: 3353-3364.
- Nakahashi-Ouchida, R., Yuki, Y. and Kiyono, H. 2018. Cationic pullulan nanogel as a safe and effective nasal vaccine delivery system for respiratory infectious diseases. Hum. Vaccine Immunother. 6: 1-27.
- Azegami, T., Yuki, Y., Nakahashi-Ouchida, R., Itoh, H. and Kiyono, H. 2018. Nanogel-based nasal vaccines for infectious and lifestyle-related diseases. Mol. Immunol. 98: 19-24.
- Shibata, N., Kunisawa, J., Hosomi, K., Fujimoto, Y., Mizote, K., Kitayama, N., Shimoyama, A., Mimuro, H., Sato, S., Kishishita, N., Ishii, KJ., Fukase, K. and Kiyono, H. 2018. Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity. Mucosal Immunol. 11: 693-702.
- Shimoyama, A., Flaviana, D.L., Yamaura, H., Mizote, K., Palmigiano, A., , Pither, M.D., Kurashima, Y., Yamamoto, D., Nelson, S., Uematsu, S., Ernst, P.B., Nakayama, T. and Kiyono, H. 2017.Mucosal mesenchymal cells: secondary barrier and peripheral educator for the gut immune system. Front. Immunol. 8: 1787.
- Kishikawa, S., Sato, S., Kaneto, S. Uchino, S., Kohsaka, S., Nakamura, S. and Kiyono, H. 2017. Allograft inflammatory factor 1 (Aif1) is a regulator of transcytosis in M cells. Nat. Commun. 8: 14509.
- Kurashima, Y. and Kiyono, H. 2017. Mucosal ecological network of epithelium and immune cells for gut homeostasis and tissue healing. Annu. Rev. Immunol. 35: 119-147.
- Nakahashi-Ouchida, R., Yuki, Y. and Kiyono, H. 2017. Development of a nanogel-based nasal vaccine as a novel antigen delivery system. Expert Rev. Vaccines 16: 1231-1240.
- Kiyono, H. and Pascual, D.W. 2020. Mucosal Vaccines 2nd Edition: Innovation for Preventing Infectious Diseases. Elsevier-Academic Press. pp.1-915.
