千葉大学災害治療学研究所

組織図・構成員

組織図・構成員

ストレス免疫治療学研究部門とは

災害等のストレスにより免疫力が低下し、易感染性となることが古くから知られている。その原因には、副腎皮質ステロイドをはじめとする内分泌系や神経系による免疫細胞機能の抑制が関与していることが示唆されているが、その詳細は依然多くの謎に包まれている。ストレス免疫治療学研究部門では、「免疫系と内分泌系・神経系の連関」という観点で、ストレスが免疫機能に及ぼす影響を分子レベルで解明し、その制御法を開発し治療応用することを目指しています。

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職位 氏名 所属 職名 researchmap
部門長 中島 裕史 医学研究院 教授 researchmap
副部門長 平原 潔 医学研究院 教授 researchmap

研究業績

中島 裕史

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  1. Hirose K, Iwata A, Tamachi T, Nakajima H. Allergic airway inflammation: key players beyond the Th2 cell pathway. Immunol Rev. 2017; 278 (1) : 145-61.
  2. Matsuki A, Takatori H, Makita S, Yokota M, Tamachi T, Suto A, Suzuki K, Hirose K, Nakajima H. T-bet inhibits innate lymphoid cell-mediated eosinophilic airway inflammation by suppressing IL-9 production. J Allergy Clin Immunol. 2017; 139 (4) : 1355-67.e6.
  3. Hosokawa J, Suzuki K, Meguro K, Tanaka S, Maezawa Y, Suto A, Fujimura L, Sakamoto A, Clevers H, Ohara O, Nakajima H. IκBNS enhances follicular helper T-cell differentiation and function downstream of ASCl2. J Allergy Clin Immunol. 2017; 140 (1) : 288-91.e8.
  4. Yokota M, Tamachi T, Yokoyama Y, Maezawa Y, Takatori H, Suto A, Suzuki K, Hirose K, Takeda K, Nakajima H. IκBNS induces Muc5ac expression in epithelial cells and causes airway hyper-responsiveness in murine asthma models. Allergy. 2017; 72 (7) : 1043-53.
  5. Ito T, Hirose K, Saku A, Kono K, Takatori H, Tamachi T, Goto Y, Renauld JC, Kiyono H, Nakajima H. IL-22 induces Reg3γ and inhibits allergic inflammation in house dust mite-induced asthma models. J Exp Med. 2017; 214 (10) : 3037-50.
  6. Tanaka S, Suto S, Iwamoto T, Kageyama T, Tamachi T, Takatori H, Suzuki K, Hirose K, Ohara O, Lefebvre V, Nakajima H. Sox12 promotes Treg differentiation in the periphery during colitis. J Exp Med. 2018; 215 (10) : 2509-19.
  7. Saku A, Hirose K, Ito T, Iwata A, Sato T, Kaji H, Tamachi T, Suto A, Goto Y, Domino SE, Narimatsu H, Kiyono H, Nakajima H. Fucosyltransferase 2 induces lung epithelial fucosylation and exacerbates house dust mite-induced airway inflammation. J Allergy Clin Immunol. 2019; 144 (3) : 698-709.e9.
  8. Saku A, Suehiro KI, Nakamura K, Nishimura N, Yokota M, Hirose K, Nakajima H. Mice lacking fucosyltransferase 2 show reduced innate allergic inflammation in the airways. Allergy. 2020; 75 (5) : 1253-6.
  9. Furuta S, Nakagomi D, Kobayashi Y, Hiraguri M, Sugiyama T, Amano K, Umibe T, Kono H, Kurasawa K, Kita Y, Matsumura R, Kaneko Y, Ninagawa K, Hiromura K, Kagami SI, Inaba Y, Hanaoka H, Ikeda K, Nakajima H; LoVAS Collaborators. Effect of reduced-dose vs high-dose glucocorticoids added to rituximab on remission induction in ANCA-associated vasculitis: A randomized clinical trial. JAMA. 2021; 325 (21) : 2178-87.
  10. Kageyama T, Ikeda K, Tanaka S, Taniguchi T, Igari H, Onouchi Y, Kaneda A, Matsushita K, Hanaoka H, Nakada TA, Ohtori S, Yoshino I, Matsubara H, Nakayama T, Yokote K, Nakajima H. Antibody responses to BNT162b2 mRNA COVID-19 vaccine and their predictors among healthcare workers in a tertiary referral hospital in Japan. Clin Microbiol Infect. 2021: S1198-743X (21) 00437-7.

平原 潔

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  1. Iwata S, Mikami Y, Sun HW, Brooks RS, Jankovic D, Hirahara K, Onodera A, Shih HY, Kawabe T, Jiang K, Nakayama T, Sher A, O'Shea JJ, Davis FP, Kanno Y. The transcription factor T-bet limits amplification of type l IFN transcriptome and circuitry in T helper 1 cells. Immunity. 2017; 46 (6) : 983-991.e4,
  2. Iinuma T, Okamoto Y, Morimoto Y, Arai T, Sakurai T, Yonekura S, Sakurai D, Hirahara K, Nakayama T. Pathogenicity of memory Th2 cells is linked to stage of allergic rhinitis. Allergy. 2018; 73 (2) : 479-489.
  3. Morimoto Y#, Hirahara K#, Kiuchi M, Wada T, Ichikawa T, Kanno T, Okano M, Kokubo K, Onodera A, Sakurai D, Okamoto Y, Nakayama T. Amphiregulin-producing pathogenic memory T helper-2 cells instruct eosinophils to secrete Osteopontin and facilitate airway fibrosis. #These authors contributed equally to this work. Immunity. 2018; 49 (1) : 134-150.e6.
  4. Obata-Ninomiya K, Ishiwata K, Nakano H, Endo Y, Ichikawa T, Onodera A, Hirahara K, Okamoto Y, Kanuka H, Nakayama T. CXCR6+ST2+ memory Th2 cells induced the expression of major basic protein in eosinophils to reduce the fecundity of helminth. Proc. Natl. Acad. Sci. USA. 2018; 115 (42) : E9849-E9858.
  5. Yamamoto T, Endo Y, Onodera A, Hirahara K, Asou H, Nakajima T, Kanno T, Ouchi Y, Uematsu S, Nishimasu H, Nureki O, Tumes DJ, Shimojo N, Nakayama T. DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells. Nat Commun. 2018; 9 (1) : 4231.
  6. Tumes D, Hirahara K, Papadopoulos M, Shinoda K, Onodera A, Kumagai J, Yip KH, Pant H, Kokubo K, Masahiro K, Aoki A, Obata-Ninomiya K, Tokoyoda K, Endo Y, Kimura MY, Nakayama T. Ezh2 controls development of natural killer T cells that cause spontaneous asthma-like pathology. J Allergy Clin Immunol. 2019; 144 (2) : 549-560.e10.
  7. Ichikawa T#, Hirahara K#, Kokubo K#, Kiuchi M, Aoki A, Morimoto Y, Kumagai J, Onodera A, Mato N, Tumes D, Goto Y, Hagiwara K, Inagaki Y, Sparwasser T, Tobe K, Nakayama T. CD103hi Treg cells constrain lung fibrosis induced by CD103low tissue-resident pathogenic CD4 T cells. #These authors contributed equally to this work. Nat Immunol. 2019; 20 (11) : 1469-1480.
  8. Sciumè G, Mikami Y, Jankovic D, Nagashima H, Villarino AV, Morrison T, Signorella S, Yao C, Sun HW, Brooks SR, Fang D, Sartorelli V, Nakayamada S, Hirahara K, Zitti B, Davis FP, Kanno Y, O'Shea JJ, Shih HY. Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells. Immunity. 2020; 53 (4) : 745-758.e4.
  9. Kiuchi M, Onodera A, Kokubo K, Ichikawa T, Morimoto Y, Kawakami E, Takayama N, Eto K, Koseki H, Hirahara K, Nakayama T. The Cxxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation. J Exp Med. 2021; 218 (4) : e20201690.
  10. Hirahara K, Aoki A, Kiuchi M, Nakayama T. Memory-type pathogenic TH2 cells and ILC2s in type 2 allergic inflammation. J. Allergy Clin. Immunol. 2021; 147 (6) : 2063-2066.

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