• 2024年
• 2023年
• 2022年
• 2021年
• 2020年
• 2019年
• 2018年
• 2017年
• 2016年
• 2015年
• 2014年
• 2013年
• 2012年
• 2011年
• 2010年以前

2024年

1. Takami M, Aoki T, Nishimura K, Tanaka H, Onodera A, Motohashi S. Anti-Vα24Jα18 TCR Antibody Tunes iNKT Cell Responses to Target and Kill CD1d-negative Tumors in an FcγRII (CD32)-dependent Manner. Cancer Res Commun. 2024; 4(2):446-459.
2. Aoki A, Iwamura C, Kiuchi M, Tsuji K, Sasaki A, Hishiya T, Hirasawa R, Kokubo K, Kuriyama S, Onodera A, Shimada T, Nagaoka T, Ishikawa S, Kojima A, Mito H, Hase R, Kasahara Y, Kuriyama N, Nakamura S, Urushibara T, Kaneda S, Sakao S, Nishida O, Takahashi K, Kimura MY, Motohashi S, Igari H, Ikehara Y, Nakajima H, Suzuki T, Hanaoka H, Nakada TA, Kikuchi T, Nakayama T, Yokote K, Hirahara K. Suppression of Type I Interferon Signaling in Myeloid Cells by Autoantibodies in Severe COVID-19 Patients. J Clin Immunol. 2024; 44(4):104.
3. Gonzalez-Avalos E, Onodera A, Samaniego-Castruita D, Rao A, Ay F. Predicting gene expression state and prioritizing putative enhancers using 5hmC signal. Genome Biol. 2024; 25(1):142.

2023年

1. Kokubo K, Hirahara K, Kiuchi M, Tsuji K, Shimada Y, Sonobe Y, Shinmi R, Hishiya T, Iwamura C, Onodera A, Nakayama T. Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism. Proc Natl Acad Sci U S A. 2023;120(2):e2218345120.
2. Yuita H, López-Moyado IF, Jeong H, Scott-Browne JP, An J, Nakayama T, Onodera A*, Ko M*, Rao A*. Inducible disruption of Tet genes results in myeloid malignancy, readthrough transcription and a heterochromatin-to-euchromatin switch. Proc Natl Acad Sci U S A. 2023; 120 (6):e2214824120. (*co-corresponding author)
3. Koyama-Nasu R, Kimura MY, Kiuchi M, Aoki A, Wang Y, Mita Y, Hasegawa I, Endo Y, Onodera A, Hirahara K, Motohashi S, Nakayama T. CD69 Imposes Tumor-Specific CD8+ T-cell Fate in Tumor-Draining Lymph Nodes. Cancer Immunol Res. 2023; 11(8):1085-1099.
4. Onodera A, Kokubo K, Okano M, Onoue M, Kiuchi M, Iwamura C, Iinuma T, Kimura MY, Ebihara N, Hanazawa T, Nakayama T, Hirahara K. Pathogenic helper T cells as the novel therapeutic targets for immune-mediated intractable diseases. Pharmacol Ther. 2023; 247:108445. (first author)

2022年

1. Onodera A, Kiuchi M, Kokubo K, Nakayama T. Epigenetic regulation of inflammation by CxxC domain-containing proteins. Immunol Rev. 2022;305(1) 137-151. (first author)
2. Kokubo K^#, Onodera A^#, Kiuchi M, Tsuji K, Hirahara K, Nakayama T. Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis. Front Immunol. 2022;13:945063. (^#co-first author)
3. Fujimoto M, Yokoyama M, Kiuchi M, Hosokawa H, Nakayama A, Hashimoto N, Sakuma I, Nagano H, Yamagata K, Kudo F, Manabe I, Lee E, Hatano R, Onodera A, Hirahara K, Yokote K, Miki T, Nakayama T, Tanaka T. Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis. Nat Commun. 2022;13(1):5408.
4. Tsuji K^#, Aoki A^#, Onodera A^#, Kiuchi M, Kokubo K, Morimoto Y, Iinuma T, Hanazawa T, Nakayama T, Hirahara K. Characterization of eosinophils and natural killer cells in nasal polyps and peripheral blood in eosinophilic chronic rhinosinusitis patients. Allergol Int. 2022;S1323-8930(22)00134-4. (^#co-first author)

2021年

1. Kiuchi M^#, Onodera A^#, Kokubo K, Ichikawa T, Morimoto Y, Kawakami E, Takayama N, Eto K, Koseki H, Hirahara K, Nakayama T. The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4⁺ T cell differentiation. J Exp Med. 2021;218(4):e20201690. (^#co-first author)
2. Onodera A, González-Avalos E, Lio CJ, Georges RO, Bellacosa A, Nakayama T, Rao, A. Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells. Genome Biol. 2021;22(1):186. (first author)
3. Nakayama T, Hirahara K, Motoko Y Kimura, Iwamura C, Kiuchi M, Kokubo K, Onodera A, Hashimoto K, Motohashi S. CD4⁺ T cells in inflammatory diseases: pathogenic T-helper cells and the CD69–Myl9 system. Int Immunol. 2021;33(12) 699-704.

2020年

1. Suzuki AS, Yagi R, Kimura MY, Iwamura C, Shinoda K, Onodera A, Hirahara K, Tumes DJ, Koyama-Nasu R, Iismaa SE, Graham RM, Motohashi S, Nakayama T. Essential role for CD30-Transglutaminase 2 axis in memory Th1 and Th17 cell generation. Front Immunol. 2020;11:1536.

2019年

1. Endo Y, Onodera A, Obata-Ninomiya K, Koyama-Nasu R, Asou HK, Ito T, Yamamoto T, Kanno T, Nakajima T, Ishiwata K, Kanuka H, Tumes DJ, Nakayama T. Acc1 determines memory potential of indivisual CD4⁺ T cells by regulating de novo fatty acid biosynthesis. Nat. Metab. 2019;1(2):261-275.
2. Tumes D, Hirahara K, Papadopoulos M, Shinoda K, Onodera A, Kumagai J, Yip KH, Pant H, Kokubo K, Kiuchi M, Aoki A, Obata-Ninomiya K, Kokoyoda K, Endo Y, Kimura MY, Nakayama T. Ezh2 controls development of natural killer T cells that cause spontaneous asthma-like pathology. J Allergy Clin Immunol. 2019;144(2):549-560.e10.
3. Seo H, Chen J, González-Avalos E, Samaniego-Castruita D, Das A, Wang YH, López-Moyado IF, Georges RO, Zhang W, Onodera A, Wu CJ, Lu LF, Hogan PG, Bhandoola A, Rao A. TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion. Proc Natl Acad Sci U S A. 2019;116(25):12410-12415.
4. Ichikawa T, Hirahara K, Kokubo K, Kiuchi M, Aoki A, Morimoto Y, Kumagai J, Onodera A, Mato N, Tumes DJ, Goto Y, Hagiwara K, Inagaki Y, Sparwasser T, Tobe K, Nakayama T. CD103hi Treg cells constrain lung fibrosis induced by CD103low tissue-resident pathogenic CD4 T cells. Nat. Immunol. 2019;20(11):1469-1480.

2018年

1. Morimoto Y, Hirahara K, Kiuchi M, Wada T, Ichikawa T, Kanno T, Okano M, Kokubo K, Onodera A, Sakurai D, Okamoto Y, Nakayama T. Amphiregulin-producing pathogenic memory T helper-2 cells instruct eosinophils to secrete Osteopontin and facilitate airway fibrosis. Immunity. 2018;49(1):134-150.e6.
2. Obata-Ninomiya K, Ishiwata K, Nakano H, Endo Y, Ichikawa T, Onodera A, Hirahara K, Okamoto Y, Kanuka H, Nakayama T. CXCR6+ST2+ memory Th2 cells induced the expression of major basic protein in eosinophils to reduce the fecundity of helminth. Proc. Natl. Acad. Sci. USA 2018;115(42):E9849-E9858.
3. Yamamoto T, Endo Y, Onodera A, Hirahara K, Asou H, Nakajima T, Kanno T, Ouchi Y, Uematsu S, Nishimasu H, Nureki O, Tumes DJ, Shimojo N, Nakayama T. DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells. Nat. Commun. 2018;9(1):4231.
4. Tanaka K, Kanesaka Y, Takami M, Suzuki A, Hosokawa H, Onodera A, Kamata T, Nagato K, Nakayama T, Yoshino I, Motohashi S. Role of leukotriene B4 12-hydroxydehydrogenase in α-galactosylceramide-pulsed dendritic cell therapy for non-small cell lung cancer. Biochem Biophys Res Commun. 2018;506(1):27-32.
5. Onodera A, Kokubo K, Nakayama T. Epigenetic and Transcriptional Regulation in the Induction, Maintenance, Heterogeneity, and Recall-Response of Effector and Memory Th2 Cells. Front Immunol. 2018;9:2929. (first author)

2017年

1. Nakayama T, Hirahara K, Onodera A, Endo Y, Hosokawa H, Shinoda K, Tumes DJ, Okamoto Y. Th2 Cells in Health and Disease. Annu Rev Immunol. 2017;35:53-84.
2. Iwata S, Mikami Y, Sun HW, Brooks SR, Jankovic D, Hirahara K, Onodera A, Shih HY, Kawabe T, Jiang K, Nakayama T, Sher A, O'Shea JJ, Davis FP, Kanno Y. The transcription factor T-bet limits amplification of type I IFN transcriptome and circuitry in T helper 1 cells. Immunity. 2017;46(6):983-991.e4.
3. Tumes DJ, Papadopoulos M, Endo Y, Onodera A, Hirahara K, Nakayama T. Epigenetic Regulation of T-helper Cell Differentiation, Memory, and Plasticity in Allergic Asthma. Immunol Rev. 2017;278(1):8-19.
4. Onodera A, Kiuchi M, Kokubo K, Kato M, Ogino T, Horiuchi S, Kanai U, Hirahara K, Nakayama T. Menin controls the memory Th2 cell function by maintaining the epigenetic integrity of Th2 cells. J. Immunol. 2017;199(3):1153-1162. (first author)
5. Ito T, Hirahara K, Onodera A, Koyama-Nasu R, Yano I, Nakayama T. Anti-tumor immunity via the superoxide-eosinophil axis induced by a lipophilic component of Mycobacterium lipomannan. Int Immunol. 2017;29(9):411-421.

2016年

1. Hayashizaki K, Kimura MY, Tokoyoda K, Hosokawa H, Shinoda K, Hirahara K, Ichikawa T, Onodera A, Hanazawa A, Iwamura C, Kakuta J, Muramoto K, Motohashi S, Tumes DJ, Iinuma T, Yamamoto H, Ikehara Y, Okamoto Y, Nakayama T. Myosin light chain 9 and 12 are functional ligands for CD69 that regulate airway inflammation. Sci. Immunol. 2016;1(3):eaaf9154.

2015年

1. Onodera A, Nakayama T. Epigenetics of T cells regulated by Polycomb/Trithorax molecules. Trends Mol Med. 2015;21:330-340. (first author)
2. Hirahara K, Onodera A, Villario AV, Bonelli M, Sciume G, Laurence A, Sun HW, Brooks SR, Vahedi G, Shih HY, Gtierrez-Cruz G, Iwata S, Suzuki R, Mikami Y, Okamoto Y, Nakayama T, Holland SM, Hunter CA, Kanno Y, O’Shea JJ. Asymmetric action of STAT transcription factors drives transcriptional outputs and cytokine specificity. Immunity. 2015;42:877-889.
3. Onodera A, Tumes DJ, Watanabe Y, Hirahara K, Kaneda A, Sugiyama F, Suzuki Y, Nakayama T. Spatial interplay between Polycomb and Trithorax complexes controls transcriptional activity in T lymphocytes. Mol Cell Biol. 2015;35:3841-3853. (first author)

2014年

1. Watanabe Y^#, Onodera A^#, Kanai U, Ichikawa T, Obata-Ninomiya K, Wada T, Kiuchi M, Iwamura C, Tumes DJ, Shinoda K, Yagi R, Motohashi S, Hirahara K, Nakayama T. Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells. Proc Natl Acad Sci USA. 2014;111:12829-12834. (^#co-first author)
2. Tanaka S, Suto A, Iwamoto T, Kashiwakuma D, Kagami S, Suzuki K, Takatori H, Tamachi T, Hirose K, Onodera A, Suzuki J, Ohara O, Yamashita M, Nakayama T, Nakajima H. Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3. J Exp Med. 2014;211:1857-1874.
3. Mishima Y, Wang C, Miyagi S, Saraya A, Hosokawa H, Mochizuki KM, Nakajima TY, Koide S, Negishi M, Sashida G, Naito T, Ishikura T, Onodera A, Nakayama T, Tenen DG, Yamaguchi N, Koseki H, Taniuchi I, Iwama A. Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development. Nat Commun. 2014;5:5872.

2013年

1. Onodera A, Tumes DJ, Nakayama T. Too much of a good thing. Nat Immunol. 2013;14:112-114. (first author)
2. Hosokawa H, Tanaka T, Suzuki Y, Iwamura C, Ohkubo S, Endoh K, Kato M, Endo Y, Onodera A, Tumes DJ, Kanai A, Sugano S, Nakayama T. Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity. Proc Natl Acad Sci USA. 2013;110:4691-4696.
3. Sasaki T, Onodera A, Hosokawa H, Watanabe Y, Horiuchi S, Yamashita J, Tanaka H, Ogawa Y, Suzuki Y, Nakayama T. Genomic-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2 cell identity. PLOS ONE. 2013;8:e66468.
4. Tumes DJ, Onodera A, Suzuki A, Shinoda K, Endo Y, Iwamura C, Hosokawa H, Koseki H, Tokoyoda K, Suzuki Y, Motohashi S, Nakayama T. The polycomb protein Ezh2 regulates differentiation and plasticity of CD4⁺ T helper type 1 and type 2 cells. Immunity. 2013;39:819-832.

2012年

1. Kuwahara M, Yamashita M, Shinoda K, Tofukuji S, Onodera A, Shinnakasu R, Motohashi S, Hosokawa H, Tumes D, Iwamura C, Lefebvre V, Nakayama, T. The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses T_H2 differentiation. Nat Immunol. 2012;13:778-786.

2011年

1. Horiuchi S^#, Onodera A^#, Hosokawa H, Watanabe Y, Tanaka T, Sugano S, Suzuki Y, Nakayama T. Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3. J Immunol. 2011;186:6378-6389. (^#co-first author)
2. Kitajima M, Ito T, Tumes DJ, Endo Y, Onodera A, Hashimoto K, Motohashi S, Yamashita M, Nishimura T, Ziegler FS, Nakayama T. Memory type 2 helper T cells induce long-lasting antitumor immunity by activating natural killer cells. Cancer Res. 2011;71:4790-4798.

2010年以前

1. Onodera A, Yamashita M, Endo Y, Kuwahara M, Tofukuji S, Hosokawa H, Kanai A, Suzuki Y, Nakayama T. STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. J Exp Med. 2010;207:2493-2506. (first author)
2. Yamashita M, Onodera A, Nakayama T. Immune mechanisms of allergic airway diseases: Regulation by transcription factors. Crit Rev Immunol. 2007;27:539-546.
3. Tenda Y, Yamashita M, Kimura YM, Hasegawa A, Shimizu C, Kitajima M, Onodera A, Suzuki A, Seki N, Nakayama T. Hyperresponsive T_H2 cells with enhanced nuclear factor-κB activation induce atopic dermatitis-like skin lesions in Nishiki-nezumi Cinnamon/Nagoya mice. J Allergy Clin Immunol. 2006;118:725-733.